An electrifying novel about illness, displacement, and what holds us together, by the author of Seeing Red Ella is an astrophysicist struggling with her doctoral thesis in the "country of the present" but she is from the "country of the past," a place burdened in her memory by both personal and political tragedies. Her partner, El, is a forensic scientist who analyzes the bones of victims of state violence and is recovering from an explosion at a work site that almost killed him. Consumed by writer's block, Ella finds herself wishing that she would become ill, which would provide time for writing and perhaps an excuse for her lack of progress. Then she begins to experience mysterious symptoms that doctors find undiagnosable. As Ella's anxiety grows, the past begins to exert a strong gravitational pull, and other members of her family come into focus: the widowed Father, the Stepmother, the Twins, and the Firstborn. Each of them has their own experience of illness and violence, and eventually the systems that both hold them together and atomize them are exposed. Lina Meruane's Nervous System is an extraordinary clinical biography of a family, full of affection and resentment, dark humor and buried secrets, in which illness describes the traumas that can be visited not just upon the body, but on families and on the history of the countries--present and past--that we live in.

A masterful, moving novel about age, memory, and family from one of the true literary icons of our time. Ptolemy Grey is ninety-one years old and has been all but forgotten-by his family, his friends, even himself-as he sinks into a lonely dementia. His grand-nephew, Ptolemy's only connection to the outside world, was recently killed in a drive-by shooting, and Ptolemy is too suspicious of anyone else to allow them into his life. until he meets Robyn, his niece's seventeen-year-old lodger and the only one willing to take care of an old man at his grandnephew's funeral. But Robyn will not tolerate Ptolemy's hermitlike existence. She challenges him to interact more with the world around him, and he grasps more firmly onto his disappearing consciousness. However, this new activity pushes Ptolemy into the fold of a doctor touting an experimental drug that guarantees Ptolemy won't live to see age ninety- two but that he'll spend his last days in feverish vigor and clarity. With his mind clear, what Ptolemy finds-in his own past, in his own apartment, and in the circumstances surrounding his grand-nephew's death-is shocking enough to spur an old man to action, and to ensure a legacy that no one will forget. In The Last Days of Ptolemy Grey, Mosley captures the compromised state of his protagonist's mind with profound sensitivity and insight, and creates an unforgettable pair of characters at the center of a novel that is sure to become a true contemporary classic.

It is the year 2072, sixty years on from the scarlet plague that decimated the earth's population. As one of the few who knew life before the plague, James Howard Smith tries to impart what he knows to his grandsons while he still can. Jack London's visionary post-apocalyptic novel The Scarlet Plague was written in 1912.

Dr. Sherwin Nuland, author of the National Book Award-winning "How We Die," once again combines knowledge, compassion, and elegance of expression to shed light on the workings of our bodies from the perspective of a surgeon. Dr. Nuland recounts age-old legends about the functions and "personalities" of the body's organs and, in riveting vignettes of the surgery he has performed, he describes the connections between myth and reality. A brilliant blend of science and folklore, "The Mysteries Within" reveals the enigmas not only of the body but also of the human imagination.

Now I find myself in late August, with the nights cool and the crickets thick in the fields. Already the first blighted leaves glow scarlet on the red maples. It’s a season of fullness and sweet longings made sweeter now by the fact that I can’t be sure I’ll see this time of the year again.... — fromLearning to Fall Philip Simmons was just thirty-five years old in 1993 when he learned that he had ALS, or Lou Gehrig’s disease, and was told he had less than five years to live. As a young husband and father, and at the start of a promising literary career, he suddenly had to learn the art of dying. Nine years later, he has succeeded, against the odds, in learning the art of living. Now, in this surprisingly joyous and spirit-renewing book, he chronicles his search for peace and his deepening relationship with the mystery of everyday life. Set amid the rugged New Hampshire mountains he once climbed, and filled with the bustle of family life against the quiet progression of illness,Learning to Fallilluminates the journey we all must take — “the work of learning to live richly in the face of loss.” From our first faltering steps, Simmons says, we may fall into disappointment or grief, fall into or out of love, fall from youth or health. And though we have little choice as to the timing or means of our descent, we may, as he affirms, “fall with grace, to grace.” With humor, hard-earned wisdom and a keen eye for life’s lessons — whether drawn from great poetry or visits to the town dump — Simmons shares his discovery that even at times of great sorrow we may find profound freedom. And by sharing the wonder of his daily life, he offers us the gift of connecting more deeply and joyously with our own.

USA Today's 5 BOOKS NOT TO MISS "Alexander nimbly and grippingly translates the byzantine world of American health care into a real-life narrative with people you come to care about." --New York Times "Takes readers into the world of the American medical industry in a way no book has done before." --Fortune "With his signature gut-punching prose, Alexander breaks our hearts as he opens our eyes to America's deep-rooted sickness and despair by immersing us in the lives of a small town hospital and the people it serves." --Beth Macy, bestselling author of Dopesick By following the struggle for survival of one small-town hospital, and the patients who walk, or are carried, through its doors, The Hospital takes readers into the world of the American medical industry in a way no book has done before. Americans are dying sooner, and living in poorer health. Alexander argues that no plan will solve America's health crisis until the deeper causes of that crisis are addressed. Bryan, Ohio's hospital, is losing money, making it vulnerable to big health systems seeking domination and Phil Ennen, CEO, has been fighting to preserve its independence. Meanwhile, Bryan, a town of 8,500 people in Ohio's northwest corner, is still trying to recover from the Great Recession. As local leaders struggle to address the town's problems, and the hospital fights for its life amid a rapidly consolidating medical and hospital industry, a 39-year-old diabetic literally fights for his limbs, and a 55-year-old contractor lies dying in the emergency room. With these and other stories, Alexander strips away the wonkiness of policy to reveal Americans' struggle for health against a powerful system that's stacked against them, but yet so fragile it blows apart when the pandemic hits. Culminating with COVID-19, this book offers a blueprint for how we created the crisis we're in.

Intensive Care is an affecting view from the trenches, a seasoned doctor's minute-by-minute and day-by-day account of life in the Intensive Care Unit (ICU) of a major inner-city hospital, San Francisco General. John F. Murray, for many years Chief of the Pulmonary and Critical Care Division of the hospital and a Professor at the University of California, San Francisco, takes readers on his daily ward rounds, introducing them to the desperately ill patients he treats as well as to the young physicians and medical students who accompany him. Writing with compassion and knowledge accumulated over a long career, Murray presents the true stories of patients who show up with myriad disorders: asthma, cardiac failure, gastrointestinal diseases, complications due to AIDS, the effects of drug and alcohol abuse, emphysema. Readers will come away from this book with a comprehensive understanding of what an ICU is, what it does, who gets admitted, and how doctors and nurses make decisions concerning life-threatening medical problems. Intensive care for critically ill patients is a new but well-established and growing branch of medicine. Estimates suggest that 15 to 20 percent of all hospitalized patients in the United States are treated in an intensive or coronary care unit during each hospital stay, so there is a real possibility that the reader will either be admitted to an ICU himself or herself or knows someone who will be. Murray not only offers a real-time account of the diagnosis, treatment, and progress of his patients over the course of one month but also conveys a wealth of information about various diseases and medical procedures in succinct and easy-to-understand terms. In addition, he elaborates on ethical dilemmas that he confronts on an almost daily basis: the extent of patient autonomy, the denial of ICU care, the withdrawal of life support, and physician-assisted suicide. Murray concludes that ICUs are doing their job, but they could be even better, cheaper, and--most important--more humane. His chronicle brings substance to a world known to most of us only through the fiction of television.

Paul Farmer has battled AIDS in rural Haiti and deadly strains of drug-resistant tuberculosis in the slums of Peru. A physician-anthropologist with more than fifteen years in the field, Farmer writes from the front lines of the war against these modern plagues and shows why, even more than those of history, they target the poor. This "peculiarly modern inequality" that permeates AIDS, TB, malaria, and typhoid in the modern world, and that feeds emerging (or re-emerging) infectious diseases such as Ebola and cholera, is laid bare in Farmer's harrowing memoir rife with stories about diseases and human suffering. Using field work and new scholarship to challenge the accepted methodologies of epidemiology and international health, Farmer points out that most current explanatory strategies, from "cost-effective treatment" to patient "noncompliance," inevitably lead to blaming the victims. In reality, larger forces, global as well as local, determine why some people are sick and others are shielded from risk. Yet this moving autobiography is far from a hopeless inventory of insoluble problems. Farmer writes of what can be done in the face of seemingly overwhelming odds, by physicians and medical students determined to treat those in need: whether in their home countries or through medical outreach programs like Doctors without Borders. Infections and Inequalities weds meticulous scholarship in medical anthropology with a passion for solutions--remedies for the plagues of the poor and the social illnesses that have sustained them.

PULITZER PRIZE FINALIST * "A stunning exposé of why Black people in our society 'live sicker and die quicker'--an eye-opening game changer."--Oprah Daily From an award-winning writer at the New York Times Magazine and a contributor to the 1619 Project comes a landmark book that tells the full story of racial health disparities in America, revealing the toll racism takes on individuals and the health of our nation. In 2018, Linda Villarosa's New York Times Magazine article on maternal and infant mortality among black mothers and babies in America caused an awakening. Hundreds of studies had previously established a link between racial discrimination and the health of Black Americans, with little progress toward solutions. But Villarosa's article exposing that a Black woman with a college education is as likely to die or nearly die in childbirth as a white woman with an eighth grade education made racial disparities in health care impossible to ignore. Now, in Under the Skin, Linda Villarosa lays bare the forces in the American health-care system and in American society that cause Black people to "live sicker and die quicker" compared to their white counterparts. Today's medical texts and instruments still carry fallacious slavery-era assumptions that Black bodies are fundamentally different from white bodies. Study after study of medical settings show worse treatment and outcomes for Black patients. Black people live in dirtier, more polluted communities due to environmental racism and neglect from all levels of government. And, most powerfully, Villarosa describes the new understanding that coping with the daily scourge of racism ages Black people prematurely. Anchored by unforgettable human stories and offering incontrovertible proof, Under the Skin is dramatic, tragic, and necessary reading.

Named a Best Book of the Year by The New Yorker and The Boston Globe An authoritative, illuminating, and deeply humane history of addiction--a phenomenon that remains baffling and deeply misunderstood despite having touched countless lives--by an addiction psychiatrist striving to understand his own family and himself "Carl Erik Fisher's The Urge is the best-written and most incisive book I've read on the history of addiction. In the midst of an overdose crisis that grows worse by the hour and has vexed America for centuries, Fisher has given us the best prescription of all: understanding. He seamlessly blends a gripping historical narrative with memoir that doesn't self-aggrandize; the result is a full-throated argument against blaming people with substance use disorder. The Urge is a propulsive tour de force that is as healing as it is enjoyable to read." --Beth Macy, author of Dopesick As a psychiatrist in training fresh from medical school, Carl Erik Fisher found himself face-to-face with an addiction crisis that nearly cost him everything. Desperate to make sense of his condition, he turned to the history of addiction, learning that our society's current quagmire is only part of a centuries-old struggle to treat addictive behavior. A rich, sweeping account that probes not only medicine and science but also literature, religion, philosophy, and public policy, The Urge introduces us to those who have endeavored to address addiction through the ages and examines the treatments that have produced relief for many people, the author included. Only by reckoning with our history of addiction, Fisher argues, can we light the way forward for those whose lives remain threatened by its hold. The Urge is at once an eye-opening history of ideas, a riveting personal story of addiction and recovery, and a clinician's urgent call for a more nuanced and compassionate view of one of society's most intractable challenges.

A triumphant memoir by the former editor-in-chief of French Elle that reveals an indomitable spirit and celebrates the liberating power of consciousness. In 1995, Jean-Dominique Bauby was the editor-in-chief of French Elle, the father of two young children, a 44-year-old man known and loved for his wit, his style, and his impassioned approach to life. By the end of the year he was also the victim of a rare kind of stroke to the brainstem. After 20 days in a coma, Bauby awoke into a body which had all but stopped working: only his left eye functioned, allowing him to see and, by blinking it, to make clear that his mind was unimpaired. Almost miraculously, he was soon able to express himself in the richest detail: dictating a word at a time, blinking to select each letter as the alphabet was recited to him slowly, over and over again. In the same way, he was able eventually to compose this extraordinary book. By turns wistful, mischievous, angry, and witty, Bauby bears witness to his determination to live as fully in his mind as he had been able to do in his body. He explains the joy, and deep sadness, of seeing his children and of hearing his aged father's voice on the phone. In magical sequences, he imagines traveling to other places and times and of lying next to the woman he loves. Fed only intravenously, he imagines preparing and tasting the full flavor of delectable dishes. Again and again he returns to an "inexhaustible reservoir of sensations," keeping in touch with himself and the life around him. Jean-Dominique Bauby died two days after the French publication of The Diving Bell and the Butterfly. This book is a lasting testament to his life.

From a leading international authority on manic-depressive illness--and one of only a handful of women who are full professors of medicine--comes a remarkable personal testimony: the revelation of her own struggle since childhood with manic-depression, and how it has shaped her life.

The compelling story of an acclaimed journalist and New York Times bestselling author's ongoing struggle with epilepsy--how, through personal resilience and the support of loved ones, heovercame medical incompetence and institutional discrimination to achieve once unthinkable success.   "REMARKABLE . . . inspirational in the true sense of the word."--The New York Times Book Review  This is the story of one man's battle to pursue his dreams despite an often incapacitating brain disorder. From his early experiences of fear and denial to his exasperating search for treatment, Kurt Eichenwald provides a deeply candid account of his years facing this misunderstood and often stigmatized condition. He details his encounters with the doctors whose negligence could have killed him, but for the heroic actions of a brilliant neurologist and the family and friends who fought for him.  Ultimately, A Mind Unraveled is an inspirational story, one that chronicles how Eichenwald, faced often with his own mortality, transformed trauma into a guide for reaching the future he desired. Praise for A Mind Unraveled "An intimate journey . . . bravely illuminating the trials of living inside a body always poised to betray itself."--O: The Oprah Magazine "Poignant and infuriating . . . merges elements of medical drama, anti-discrimination fable, and coming-of-age memoir."--The New Yorker "One of the best thrillers I've read in years, yet there are no detectives, no corpses, no guns or knives."--Minneapolis Star-Tribune "Terrific . . . Eichenwald's narrative is a suspenseful medical thriller about a condition that makes everyday life a mine field, a fierce indictment of a callous medical establishment, and an against-the-odds recovery saga."--Publishers Weekly (starred review) "Riveting . . . Eichenwald has created a universal tale of resilience wrapped in a primal scream against the far-too-savage world."--Booklist (starred review) "An extraordinary book."--Harriet Lerner, Ph.D., New York Times bestselling author of The Dance of Anger

New York Times bestseller One of the top ten books of the year at The New York Times Book Review, The Wall Street Journal, Vulture/New York magazine A best book of the year at Los Angeles Times, Time, NPR, The Washington Post, Bookforum, The New Yorker, Vogue, Kirkus The acclaimed, award-winning New Yorker writer Rachel Aviv offers a groundbreaking exploration of mental illness and the mind, and illuminates the startling connections between diagnosis and identity. Strangers to Ourselves poses fundamental questions about how we understand ourselves in periods of crisis and distress. Drawing on deep, original reporting as well as unpublished journals and memoirs, Rachel Aviv writes about people who have come up against the limits of psychiatric explanations for who they are. She follows an Indian woman celebrated as a saint who lives in healing temples in Kerala; an incarcerated mother vying for her children's forgiveness after recovering from psychosis; a man who devotes his life to seeking revenge upon his psychoanalysts; and an affluent young woman who, after a decade of defining herself through her diagnosis, decides to go off her meds because she doesn't know who she is without them. Animated by a profound sense of empathy, Aviv's gripping exploration is refracted through her own account of living in a hospital ward at the age of six and meeting a fellow patient with whom her life runs parallel--until it no longer does. Aviv asks how the stories we tell about mental disorders shape their course in our lives--and our identities, too. Challenging the way we understand and talk about illness, her account is a testament to the porousness and resilience of the mind.

Michele Harper is a female, African American emergency room physician in a profession that is overwhelmingly male and white. Her marriage at an end, Harper began her new life in a new city, in a new job, as a newly single woman. The Beauty in Breaking is the poignant true story of Harper's journey toward self-healing. Each of the patients Harper writes about taught her something important about recuperation and recovery.

No disease the world has ever known even remotely resembles the great influenza epidemic of 1918. Presumed to have begun when sick farm animals infected soldiers in Kansas, spreading and mutating into a lethal strain as troops carried it to Europe, it exploded across the world with unequaled ferocity and speed. It killed more people in twenty weeks than AIDS has killed in twenty years; it killed more people in a year than the plagues of the Middle Ages killed in a century. Victims bled from the ears and nose, turned blue from lack of oxygen, suffered aches that felt like bones being broken, and died. In the United States, where bodies were stacked without coffins on trucks, nearly seven times as many people died of influenza as in the First World War. In his powerful new book, award-winning historian John M. Barry unfolds a tale that is magisterial in its breadth and in the depth of its research, and spellbinding as he weaves multiple narrative strands together. In this first great collision between science and epidemic disease, even as society approached collapse, a handful of heroic researchers stepped forward, risking their lives to confront this strange disease. Titans like William Welch at the newly formed Johns Hopkins Medical School and colleagues at Rockefeller University and others from around the country revolutionized American science and public health, and their work in this crisis led to crucial discoveries that we are still using and learning from today. The Washington Post's Jonathan Yardley said Barry's last book can ?change the way we think.' The Great Influenzamay also change the way we see the world.

A story of courage and risk-taking, "House on Fire" tells how smallpox, a disease that killed, blinded, and scarred millions over centuries of human history, was completely eradicated in a spectacular triumph of medicine and public health. Part autobiography, part mystery, the story is told by a man who was one of the architects of a radical vaccination scheme that became a key strategy in ending the horrible disease when it was finally contained in India. In House on Fire, William H. Foege describes his own experiences in public health and details the remarkable program that involved people from countries around the world in pursuit of a single objective eliminating smallpox forever. Rich with the details of everyday life, as well as a few adventures, "House on Fire" gives an intimate sense of what it is like to work on the ground in some of the world s most impoverished countries and tells what it is like to contribute to programs that really do change the world."

When people ask Elizabeth Pisani what she does for a living, she says, "sex and drugs." As an epidemiologist researching AIDS, she's been involved with international efforts to halt the disease for fourteen years. With swashbuckling wit and fierce honesty, she dishes on herself and her colleagues as they try to prod reluctant governments to fund HIV prevention for the people who need it most--drug injectors, gay men, sex workers, and johns.Pisani chats with flamboyant Indonesian transsexuals about their boob jobs and watches Chinese streetwalkers turn away clients because their SUVs aren't nice enough. With verve and clarity, she shows the general reader how her profession really works; how easy it is to draw wrong conclusions from "objective" data; and, shockingly, how much money is spent so very badly. "Exhibit A": the 45 billion taxpayer dollars the Bush administration is committing to international AIDS programs.

Vaccinating America: The Inside Story Behind the Race to Save Lives, and End a Pandemic spotlights the public servants and heroes who planned and executed this unprecedented program to combat COVID-19 amidst fierce partisan divides, bureaucratic infighting and overwhelming logistical challenges, and doesn't hold back on pointing out those who hindered progress.

**The instant New York Times bestseller.** *An international bestseller.* "Hugely impressive, a major work."--NPR A pioneering and groundbreaking work of narrative nonfiction that offers a dramatic new perspective on the history of humankind, showing how through millennia, the mosquito has been the single most powerful force in determining humanity's fate   Why was gin and tonic the cocktail of choice for British colonists in India and Africa? What does Starbucks have to thank for its global domination? What has protected the lives of popes for millennia? Why did Scotland surrender its sovereignty to England? What was George Washington's secret weapon during the American Revolution? The answer to all these questions, and many more, is the mosquito.   Across our planet since the dawn of humankind, this nefarious pest, roughly the size and weight of a grape seed, has been at the frontlines of history as the grim reaper, the harvester of human populations, and the ultimate agent of historical change. As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.   The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.   Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.   Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

A profoundly moving account of an oncology nurse's conversations with the dying.

A Little Life follows four college classmates—broke, adrift, and buoyed only by their friendship and ambition—as they move to New York in search of fame and fortune. While their relationships, which are tinged by addiction, success, and pride, deepen over the decades, the men are held together by their devotion to the brilliant, enigmatic Jude, a man scarred by an unspeakable childhood trauma. A hymn to brotherly bonds and a masterful depiction of love in the twenty-first century, Hanya Yanagihara’s stunning novel is about the families we are born into, and those that we make for ourselves

This groundbreaking and life-changing work based on the latest research effectively demonstrates "the profound impact that love, connection, and kindness have on our health" (Mark Williamson, PhD, director of Action for Happiness). When Columbia University doctor Kelli Harding began her clinical practice, she never intended to explore the invisible factors behind our health. But then there were the rabbits. In 1978, a seemingly straightforward experiment designed to establish the relationship between high blood cholesterol and heart health in rabbits discovered that kindness--in the form of a particularly nurturing post-doc who pet and spoke to the lab rabbits as she fed them--made the difference between a heart attack and a healthy heart. As Dr. Kelli Harding reveals in this eye-opening book, the rabbits were just the beginning of a much larger story. Groundbreaking new research shows that love, friendship, community, and our environment can have a greater impact on our health than anything that happens in the doctor's office. For instance, chronic loneliness can be as unhealthy as smoking a pack of cigarettes a day; napping regularly can decrease one's risk of heart disease; and people with purpose are less likely to get sick. At once paradigm-shifting and empowering, The Rabbit Effect illuminates vital public health research showing kindness in our day-to-day lives can make the "world a healthier, happier place. I recommend this book highly for anyone who wants to live more healthfully" (Christy Turlington Burns, and CEO of Every Mother Counts).

NEW YORK TIMES BESTSELLER * Read with Jenna Book Club Pick as Featured on Today * As a young mother facing a terminal diagnosis, Julie Yip-Williams began to write her story, a story like no other. What began as the chronicle of an imminent and early death became something much more--a powerful exhortation to the living. "An exquisitely moving portrait of the daily stuff of life."--The New York Times Book Review (Editors' Choice) NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review * Time * Real Simple * Good Housekeeping That Julie Yip-Williams survived infancy was a miracle. Born blind in Vietnam, she narrowly escaped euthanasia at the hands of her grandmother, only to flee with her family the political upheaval of her country in the late 1970s. Loaded into a rickety boat with three hundred other refugees, Julie made it to Hong Kong and, ultimately, America, where a surgeon at UCLA gave her partial sight. She would go on to become a Harvard-educated lawyer, with a husband, a family, and a life she had once assumed would be impossible. Then, at age thirty-seven, with two little girls at home, Julie was diagnosed with terminal metastatic colon cancer, and a different journey began. The Unwinding of the Miracle is the story of a vigorous life refracted through the prism of imminent death. When she was first diagnosed, Julie Yip-Williams sought clarity and guidance through the experience and, finding none, began to write her way through it--a chronicle that grew beyond her imagining. Motherhood, marriage, the immigrant experience, ambition, love, wanderlust, tennis, fortune-tellers, grief, reincarnation, jealousy, comfort, pain, the marvel of the body in full rebellion--this book is as sprawling and majestic as the life it records. It is inspiring and instructive, delightful and shattering. It is a book of indelible moments, seared deep--an incomparable guide to living vividly by facing hard truths consciously. With humor, bracing honesty, and the cleansing power of well-deployed anger, Julie Yip-Williams set the stage for her lasting legacy and one final miracle: the story of her life. Praise for The Unwinding of the Miracle "Everything worth understanding and holding on to is in this book. . . . A miracle indeed."--Kelly Corrigan, New York Times bestselling author "A beautifully written, moving, and compassionate chronicle that deserves to be read and absorbed widely."--Siddhartha Mukherjee, Pulitzer Prize-winning author of The Emperor of All Maladies

A NEW YORK TIMES BESTSELLER FINALIST FOR THE 2022 NATIONAL BOOK AWARD FOR NONFICTION Named one of the BEST BOOKS OF 2022 by NPR, The New Yorker, Time, and Vogue "Remarkable." -Andrew Solomon, The New York Times Book Review "At once a rigorous work of scholarship and a radical act of empathy."--Esquire "A ray of light into those isolated cocoons of darkness that, at one time or another, may afflict us all." --The Wall Street Journal "Essential."--The Boston Globe A landmark exploration of one of the most consequential and mysterious issues of our time: the rise of chronic illness and autoimmune diseases A silent epidemic of chronic illnesses afflicts tens of millions of Americans: these are diseases that are poorly understood, frequently marginalized, and can go undiagnosed and unrecognized altogether. Renowned writer Meghan O'Rourke delivers a revelatory investigation into this elusive category of "invisible" illness that encompasses autoimmune diseases, post-treatment Lyme disease syndrome, and now long COVID, synthesizing the personal and the universal to help all of us through this new frontier.   Drawing on her own medical experiences as well as a decade of interviews with doctors, patients, researchers, and public health experts, O'Rourke traces the history of Western definitions of illness, and reveals how inherited ideas of cause, diagnosis, and treatment have led us to ignore a host of hard-to-understand medical conditions, ones that resist easy description or simple cures. And as America faces this health crisis of extraordinary proportions, the populations most likely to be neglected by our institutions include women, the working class, and people of color.   Blending lyricism and erudition, candor and empathy, O'Rourke brings together her deep and disparate talents and roles as critic, journalist, poet, teacher, and patient, synthesizing the personal and universal into one monumental project arguing for a seismic shift in our approach to disease. The Invisible Kingdom offers hope for the sick, solace and insight for their loved ones, and a radical new understanding of our bodies and our health.